Substraten voor neuropsychologisch functioneren bij verslaving aan stimulerende middelen

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Stimulant dependence is associated with neuropsychological impairments. Here, we summarize and integrate the existing neuroimaging literature on the neural
substrates of neuropsychological (dys)function in stimulant dependence, including cocaine, (meth-)amphetamine, ecstasy and nicotine dependence, and excessive caffeine use, comparing stimulant abusers (SAs) to nondrug using healthy controls (HCs). Despite some inconsistencies, most studies indicated altered brain activation in prefrontal cortex (PFC) and insula in response to reward and punishment, and higher limbic and anterior cingulate cortex (ACC)/PFC activation during craving and attentional bias paradigms in SAs compared with HCs. Impulsivity in SAs was associated with lower ACC and presupplementary motor area activity compared with HCs, and related to both ventral (amygdala, ventrolateral PFC, insula) and dorsal (dorsolateral PFC, dorsal ACC, posterior parietal cortex) systems. Decision making in SAs was associated with low dorsolateral PFC activity and high orbitofrontal activity. Finally, executive function in SAs was associated with lower activation in frontotemporal regions and higher activation in premotor cortex compared with HCs. It is concluded that the lower activations compared with HCs are likely to reflect the neural substrate of impaired neurocognitive functions, whereas higher activations in SAs compared with HCs are likely to reflect compensatory cognitive control mechanisms to keep behavioral task performance to a similar level as in HCs. However, before final conclusions can be drawn, additional research is needed using neuroimaging in SAs and HCs using larger and more homogeneous samples as well as more comparable task paradigms, study designs, and statistical analyses.


Crunelle CL, Veltman DJ, Booij J, van Emmerik – van Oortmerssen K, van den Brink W. Substrates of Neuropsychological Functioning in Stimulant Dependence: a Review of Functional Neuroimaging Research Brain Behav. 2012 Jul; 2(4): 499-523


Vrije Universiteit Brussel (VUB), UZ Brussel, Afdeling Psychiatrie & Universiteit Antwerpen, Toxicologisch Centrum
dr. Cleo Crunelle

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Startdatum 01/01/2008
Einddatum 31/05/2012




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Datum laatste wijziging: 14/08/2017
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