Disfunctionele amygdala activatie en connectiviteit met de prefrontale cortex in cocaine gebruikers

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Hyperactivity of the amygdala, thalamus, and hippocampus and reduced amygdala connectivity with the anterior cingulate gyrus in response to angry and fearful facial expressions are observed in current cocaine users compared to controls. Increased amygdala activation was independently associated with earlier age of first cocaine use and with longer exposure to cocaine.

Amygdala hyperactivity to biologically salient stimuli may represent a risk factor for an early onset of cocaine use and prolonged cocaine use may further sensitize amygdala activation. High amygdala activation to emotional face processing in current cocaine users may result from low prefrontal control of the amygdala response to such stimuli.


Crunelle CL,Kaag AM, van den Munkhof HE, Reneman L, Homberg J, Sabbe B, van den Brink W, van Wingen G (2015). Dysfunctional amygdala activation and connectivity with the prefrontal cortex in current cocaine users. Human Brain Mapping 2015 Jul 28. doi: 10.1002/hbm.22913.


Vrije Universiteit Brussel (VUB), UZ Brussel, Afdeling Psychiatrie & Universiteit Antwerpen, Toxicologisch Centrum
dr. Cleo Crunelle

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Startdatum 01/01/2013
Einddatum 01/01/2015


Illegale drugs





Datum laatste wijziging: 14/08/2017
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