Disfunctionele amygdala activatie en connectiviteit met de prefrontale cortex in cocaine gebruikers
Samenvatting
Hyperactivity of the amygdala, thalamus, and hippocampus and
reduced amygdala connectivity with the anterior cingulate gyrus in
response to angry and fearful facial expressions are observed in current cocaine
users compared to controls. Increased amygdala activation was
independently associated with earlier age of first cocaine use and with
longer exposure to cocaine.
Amygdala hyperactivity to biologically salient stimuli may represent a risk factor for an early onset of cocaine use and prolonged cocaine use may further sensitize amygdala activation. High amygdala activation to emotional face processing in current cocaine users may result from low prefrontal control of the amygdala response to such stimuli.
Output
Crunelle CL,Kaag AM, van den Munkhof HE, Reneman L, Homberg J, Sabbe B, van den Brink W, van Wingen G (2015). Dysfunctional amygdala activation and connectivity with the prefrontal cortex in current cocaine users. Human Brain Mapping 2015 Jul 28. doi: 10.1002/hbm.22913.
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Einddatum 01/01/2015
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Datum laatste wijziging: 14/08/2017
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