Analyse van quetiapine en 7-OH-quetiapine in haar met LC/MS-MS

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Samenvatting

Hair analysis is a powerful tool for retrospective drug analysis and has a wide application window. This article describes the simultaneous determination and quantification of the short-acting atypical antipsychotic drug quetiapine and its main metabolite 7-OH quetiapine in hair. A sensitive and accurate method for the determination of these two compounds was developed using high-performance liquid chromatography coupled to tandem mass spectrometry detection (LC–MS/MS). The method was applied to 10 real case samples. For five patients, a time resolved hair analysis was done. Results varied from 0.35 ng/mg to 10.21 ng/mg hair for quetiapine and from 0.02 ng/mg to 3.19 ng/mg hair for 7-OHquetiapine.

Doelstelling

Output

Binz TM, Yegles M, Schneider S, Neels H, Crunelle CL . Time resolved analysis of quetiapine and 7-OH-quetiapine in hair using LC/MS-MS. Forensic Sci Int. 2014 Sep; 242:200-203.

Contact

Universiteit Antwerpen, Toxicologisch Centrum & Vrije Universiteit Brussel (VUB), UZ Brussel, Afdeling Psychiatrie
dr. Cleo Crunelle

Algemene info

Looptijd

Startdatum 01/01/2012
Einddatum 01/01/2014

Product

Psychoactieve medicatie

Regio

Internationaal

Status

Afgerond

Datum laatste wijziging: 14/08/2017
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